ANTIULCER ACTIVITY OF PLACENTAL CRYOEXTRACT IN EXPERIMENTAL INDOMETHACIN-INDUCED ULCEROGENESIS

Aim. The side effects associated with the use of indometacin are noted by about 30-60% patients, therefore, in this context problem adverse event rate reduction is still relevant today. Cryopreserved placental extract (CEP) attracted our attention as a means pathogenetic correction ulcerogenic action indomethacin. aim paper to characterize antiulcer activity cryopreserved placenta on model indomethacin-induced ulcerogenesis.
 Materials and Methods. In vivo experimental studies were performed 28 nonlinear laboratory male rats weighing 200-220 g. Acute gastrointestinal injury was replicated single injection indomethacin at 60 mg/kg rats. Euthanasia animals after 4 hours administration.
 Results Discussion. Macroscopic evaluation condition gastric mucosa showed that all had numerous pinpoint hemorrhages, 49.2% mild hyperemia abnormal folding. Evaluation small intestinal 57.1% injected alone 11.1±4.1 ulcers per 10 cm length. Prophylactic administration esomeprazole led statistically significant (p<0.05) attenuation effect - mean score 3.9 times lower than control 0.9±0.26.
 Conclusions. combined CEP 1.9-fold ulcer index compared administered only, thus demonstrating gastroprotective CEP. contrast esomeprazole, introduction has pronounced enteroprotective effect, indicated absence damage treated studied cryoextract